Joe’s white blood cells are collected1,2

  • His cells are sent to a central manufacturing facility1
  • His T cells are isolated and activated2

Joe’s T cells are genetically engineered to express
a chimeric antigen receptor (CAR)1,2

  • A retroviral vector transduces
    T cells with the CAR construct3
  • His CAR T cells increase in number1,2
  • Engineering process takes approximately 2 weeks

CAR T cells are infused back into Joe1,2

  • His CAR T cells replicate and expand in vivo1
  • His CAR T cells are designed
    to recognize
    and attack cancer cells3
References: 1. Sharpe M, Mount N. Dis Model Mech. 2015;8(4):337-350. 2. Wang X, Riviere I. Mol Ther
Oncolytics.
2016;3:16015. 3. Kochenderfer JN, Rosenberg SA. Nat Rev Clin Oncol. 2013;10(5):267-276.